Week 2 of the 2026 season delivers a landmark primetime game and a full slate of early-season storylines. The NFL Week 2 Schedule opens Thursday, September 17, when the Detroit Lions visit the Buffalo Bills for the first regular-season contest at the new Highmark Stadium.
That matchup kicks off Amazon’s Thursday Night Football package at 8:15 p.m. ET. The league has traditionally used the second week to showcase new venues, and Buffalo’s state-of-the-art home gets the national spotlight.
Sunday, September 20, brings the bulk of the action across the usual afternoon and evening windows. Monday Night Football closes the week on September 21 with the New York Giants traveling to face the Los Angeles Rams.
Complete NFL Week 2 Schedule 2026
Thursday, September 17 Detroit Lions at Buffalo Bills 8:15 p.m. ET – Amazon Prime Video
Sunday, September 20 1:00 p.m. ET Carolina Panthers at Atlanta Falcons – FOX New Orleans Saints at Baltimore Ravens – CBS Minnesota Vikings at Chicago Bears – FOX Cincinnati Bengals at Houston Texans – CBS Pittsburgh Steelers at New England Patriots – CBS Green Bay Packers at New York Jets – FOX Cleveland Browns at Tampa Bay Buccaneers – CBS Philadelphia Eagles at Tennessee Titans – FOX
4:05 p.m. ET Jacksonville Jaguars at Denver Broncos – CBS Las Vegas Raiders at Los Angeles Chargers – CBS
4:25 p.m. ET Seattle Seahawks at Arizona Cardinals – FOX Washington Commanders at Dallas Cowboys – FOX Miami Dolphins at San Francisco 49ers – FOX
8:20 p.m. ET Indianapolis Colts at Kansas City Chiefs – NBC / Peacock
Monday, September 21 New York Giants at Los Angeles Rams 8:15 p.m. ET – ESPN / ABC
How to watch the games
Amazon Prime Video carries the Thursday night opener exclusively. CBS games stream on Paramount+. FOX games are available on the FOX app and FOX One. NBC’s Sunday night game streams on Peacock. ESPN/ABC Monday Night Football is available on the ESPN app and major live-TV services such as Fubo, YouTube TV and Hulu + Live TV.
Regional games follow the usual local-market blackouts. NFL+ offers mobile streaming of in-market and primetime contests for subscribers.
Why this week stands out
The new Highmark Stadium debut gives Buffalo a rare national stage in Week 2. Pairing the Bills with a strong Lions team creates an early measuring-stick game for two contenders.
Elsewhere, the slate mixes rematches from recent seasons with fresh cross-conference matchups. Several teams will be looking to rebound quickly after Week 1 results, while others aim to build early momentum.
MORE: 2026 NFL Schedule: Complete Team-by-Team Season Guide
Mark the dates. The second week of the season already carries weight, and the full NFL schedule week 2 delivers both a historic stadium opener and a deep Sunday slate.
FAQ
When does Week 2 of the 2026 NFL season start? Thursday, September 17, with the Detroit Lions at the Buffalo Bills at 8:15 p.m. ET on Amazon Prime Video.
What is the complete Week 2 NFL Schedule 2026? The week runs from Thursday, Sept. 17 through Monday, Sept. 21 and includes the Highmark Stadium debut, a full Sunday slate, and Monday Night Football.
How to watch the Lions-Bills game? The Thursday Night Football matchup streams exclusively on Amazon Prime Video.
Which networks carry the Sunday and Monday games? CBS, FOX, NBC and ESPN/ABC share the remaining package, with corresponding streaming options on Paramount+, the FOX platforms, Peacock and the ESPN app.
